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Dr. Vanlandingham

Dana Vanlandingham, Ph.D.

Assistant Professor, Department of Pathology

University of Texas Medical Branch
301 University Blvd,
Galveston, TX 77555-0609

Office: (409) 266-6903
Lab (409) 772-2511
dlvanlan@utmb.edu

Professional Education

Degree Institution Field of Study Graduation Year
BS

Colorado State University

 Microbiology 1993
MS Colorado State University Microbiology 1996
Ph.D. Liverpool School of Tropical Medicine Tropical Medicine 2006

Honors

2009–present Scholars in Education 18 month program, UTMB. Project Title: Practical Training for Work in ACL3 Facilities.
2009 Bromberg Workshop in Teaching and Mentoring, UTMB
2006–2009 Postdoctoral Research Training Award (T32 A107536). NIAID Training in Emerging and Reemerging Infectious Diseases, UTMB
2003 International Bioinformatics Workshop—Malaria Vectors. MR4. Full Scholarship and Travel Award.
1994 Public Health Service Group Award. Awarded to the Division of Vector-Borne Infectious Diseases Arbovirus Surveillance Group.

Research Interests

My research interests at UTMB focus on the interactions between arboviruses, the mosquito vector, and the vertebrate host. Using infectious clone technology to develop chimeric alphaviruses with segments from o’nyong-nyong and chikungunya viruses, and the mosquito vectors, Aedes aegypti and Anopheles gambiae, we are studying the viral molecular determinants involved in vector species specificity. Using microarray technology, we are also investigating the role of mosquito genes that are differentially expressed following exposure to an infectious bloodmeal.  I am also interested the molecular determinants of viral infection and dissemination within the mosquito. For this project, I am working with chimeric flavivirus infectious clones to examine the basis of viral dissemination of yellow fever wild type and vaccine viruses in Ae. aegypti mosquitoes. A new project focuses on the analysis of molecular changes which occur in Rift Valley Fever virus following replication of the virus in the mosquito or vertebrate host. Through these studies, we will gain a better understanding of the interactions between arboviruses in the mosquito vector and the vertebrate host.

Selected Publications

  1. Attardo, G.M., Higgs, S., Klingler, K.A., Vanlandingham, D.L., Raikhel, A.S. 2003. RNA interference-mediated knockdown of a GATA factor reveals a link to anautogeny in the mosquito Aedes aegypti. Proc. Nat. Acad. Sci. 100: 13374-13379.
  2. Vanlandingham, D.L., Schneider, B.S., Klingler, K., Fair, J., Beasley, D., Huang, J., Hamilton, P., Higgs, S. 2004. Real-time reverse transcriptase-polymerase chain reaction quantification of West Nile virus transmitted by Cx. pipiens quinquefasciatus. Am. J. Trop. Med. Hyg. 71: 120-123.
  3. Vanlandingham, D.L., Hong, C., Tsetsarkin, K., McElroy, K.L., Powers, A.M., Lehane, M.J., Higgs, S. 2005. Differential infectivities of Chikungunya and O’nyong-nyong virus isolates in An. gambiae and Aedes aegypti mosquitoes. Am J Trop Med Hyg. 72: 616-621.
  4. McElroy, K.L., Tsetsarkin, K.A., Vanlandingham, D.L., Higgs, S. 2005. Characterization of an infectious clone of the wild-type yellow fever virus Asibi strain that is able to infect and disseminate in mosquitoes. J Gen Virol. 86: 1747-1751.
  5. Higgs, S., Schneider, B.S., Vanlandingham, D.L., Klingler, K., Gould, E.A. 2005. Nonviremic transmission of West Nile virus. Proc Natl Acad Sci. 102: 8871-8874.
  6. Vanlandingham, D.L., Tsetsarkin, K., Hong, C., Klingler, K., McElroy, K.L., Lehane, M.J., Higgs, S. 2005. Development and characterization of a double subgenomic chikungunya virus infectious clone to express heterologous genes in Aedes aegypti mosquitoes. Insect Biochem Mol. 35: 1162-1170.
  7. Abraham, E.G., Pinto, S., Ghonsh, A., Vanlandingham, D.L., Budd, A., Higgs, S., Kafatos, F.C., Jacobs-Lorena, M., Michel, K. 2005. An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. Proc Natl Acad Sci. 102: 16327-16332.
  8. Vanlandingham, D.L., Tsetsarkin, K., Klingler, K.A., Hong, C., McElroy, K.L., Lehane, M.J., Higgs, S. 2006. Determinants of vector specificity of O’nyong nyong and Chikungunya viruses in Anopheles and Aedes mosquitoes. Am. J. Trop. Med. Hyg. 74: 663-669.
  9. McElroy, K.L., Tsetsarkin, K.A., Vanlandingham, D.L., Higgs, S. 2006. Role of the yellow fever virus structural protein genes in viral dissemination from the Aedes aegypti mosquito midgut. J. Gen. Virol. 87:2993-3001.
  10. Tsetsarkin, K.A., Higgs, S., McGee, C.E., de Lamballerie, X., Charrel, R.N., Vanlandingham, D.L. 2006. Infectious clones of Chikungunya virus (La Reunion isolate) for vector competence studies. Vector-borne and Zoonotic Diseases. 4: 325-337.
  11. McElroy, K.L., Tsetsarkin, K.A., Vanlandingham, D.L., and Higgs, S. 2006. Manipulation of the Yellow Fever virus non-structural genes 2A and 4B and the 3 ' non-coding region to evaluate genetic determinants of viral dissemination from the Aedes aegypti midgut. Am J Trop Med Hyg. 7: 1156-1164.
  12. McGee, C.E., Schneider, B.S., Girard, Y.A., Vanlandingham, D.L., Higgs, S. 2007. Nonviremic transmission of West Nile virus: Evaluation of the effects of space, time and mosquito species. Am J Trop Med Hyg. 76:424-430.
  13. Sim, C., Hong, Y.S., Tsetsarkin, K., Vanlandingham, D.L., Higgs, S., Collins, F.H. 2007. Anopheles gambiae HSC70B impedes o’nyong-nyong virus replication. BMC Genomics. 11: 231. PMID: 17625007
  14. Vanlandingham, D.L., McGee, C.E., Klingler, K, Higgs, S. 2007. Relative susceptibilities of South Texas mosquitoes to infection with West Nile Virus. Am J Trop Med Hyg. 77 :925-928. PMID: 17984355
  15. Tsetsarkin, K.A., Vanlandingham, D.L., McGee, C.E., Higgs, S. 2007. A single mutation in Chikungunya virus effects vector specificity and epidemic potential. PLoS. 7;3(12):e201. PMID: 18069894
  16. Vanlandingham, D.L., McGee, C.E., Klingler, K, Galbraith, S.A., Barrett, A.D.T., Higgs, S. 2008. Comparison of oral infectious dose of West Nile virus isolates representing three distinct genotypes in Culex pipiens quinquefasciatus.  Trop Med Hyg. 79:951-954. PMID: 19052310
  17. McGee, C.E., Shustov, A.V., Tsetsarkin, K., Frolov, I.V., Mason, P.W., Vanlandingham, D.L & Higgs, S. 2009. Infection, Dissemination, and Transmission of a West Nile virus Green Fluorescent Protein Infectious Clone by Culex pipiens quinquefasciatus Mosquitoes. Vector- Borne and Zoonotic Diseases (e published). Journal 2009, 6:73. PMID: 19619041
  18. Fros, J.J., Liu, W.J., Prow, N.A., Geertsema, C., Ligtenberg, M., Vanlandingham, D.L., Schnettler, E., Vlak, J.M., Khromykh, A.A., Pijlman, G.P. Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling.  Journal of Virology. 2010.
  19. Alvarez, K., Arensburger, P., Atkinson, P., Bartholomay, L., Birren, B., Bryant, B., Campbell, C., Chapman, S., Christensen, B., Christophides, G., Clem, R., Das, S., Dimopoulos, G., Erickson, S., Hemingway, Jlk Higgs, S., Karunaratne, P., Kodira, C., Kokoza, V., Mayhew, G., Megy, K., Michel, K., Muskavitch, M., Raikgel, A., Ramirex, J., Ranson, H., Shin, S., Vanlandingham, D., Waterhouse, R., Zdobnov, E., Zhou, Z. Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to multiple pathogens. Science 2010. In Press.
  20. Thangamani, S., Higgs, S., Ziegler, S., Vanlandingham, D.L., Tesh, R., Wikel, S. Host immune response to mosquito-transmitted chikungunya virus differs from that elicited by needle inoculated virus. PLoS One. 2010. 5 e12137

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